Seth Doege and No. 23 Texas Tech thought they'd never get beaten as badly as during a 60-point loss to Oklahoma State last season.
The rematch wasn't much better.
Isaiah Anderson had a career-best 174 yards receiving and caught three long touchdown passes from Clint Chelf in his final home game, leading Oklahoma State to a 59-21 win against the Red Raiders on Saturday.
Zack Craig blocked a pair of punts, returning one for a touchdown, as the Cowboys (7-3, 5-2 Big 12) won their fourth straight in the series and the second in a row in decisive fashion.
The Red Raiders had a chance to pass the defending conference champions in the Big 12 standings, and perhaps secure a better bowl destination, but instead dropped their fifth straight game in Stillwater in another blowout.
Doege threw for 230 yards with two interceptions and a single touchdown pass for Texas Tech (7-4, 4-4). He started the day leading the Bowl Subdivision with 34 touchdown passes this season.
The Cowboys sacked Doege three times in the first half and Tyler Johnson was pressuring him again to force an ill-advised throw that Shamiel Gary intercepted. Just two plays later, Chelf connected with Anderson on a 33-yard flea flicker pass to push the Oklahoma State advantage to 21-7.
Tech couldn't respond and followed that by going three-and-out, with Craig rushing in to block Ryan Erxleben's punt and keep Oklahoma State's roll going. J.W. Walsh finished the ensuing drive with a 2-yard TD run on a quarterback keeper, and Chelf threw a 66-yard touchdown pass to Anderson on the first play after another Red Raiders three-and-out.
Chelf passed for 229 yards in his second career start. Walsh, who had what coach Mike Gundy called a season-ending injury four weeks ago, ran for one touchdown and threw for another out of a short-yardage package.
Anderson was on the receiving end of scoring passes of 60, 33 and 66 yards from Chelf and ended up with nearly three times his previous career-best of 64 yards receiving in a game.
Joseph Randle and Jeremy Smith each tacked on touchdown runs for Oklahoma State in the second half, and Quinn Sharp matched his career-long with a 51-yard field goal. Craig's punt block extended the lead to 59-14 early in the fourth quarter.
It wasn't the complete dominance as last season, when Oklahoma State was up 35-0 after the first quarter and 49-0 by halftime. But it wasn't far off.
"You're just trying to go out and win. It doesn't really matter how it happens," Chelf said. "They're a good team, but we came to play today with a lot of energy and wanted to send the seniors off right."