Oklahoma scored the first 10 points in three minutes and the No. 18 Sooners never let up in an 80-52 defeat of Creighton on Sunday afternoon.
The Sooners (5-2), coming off a loss to unranked UCLA, built leads of as many as 35 points behind the shooting of Sharane Campbell, who was 10-for-14 from the field for a career-high 25 points.
Aaryn Ellenberg added 13 points and 10 rebounds, Nicole Griffin 17 points and nine boards.
Marissa Janning, with 18 points, was the only player to reach double figures for the Bluejays (4-3). Janning scored all her points on 3-point baskets -- she was 6 of 13 from behind the arc, matching a career high.
Creighton lobbed 41 3-pointers, hitting just 11 and was an icy 21 percent field-goal shooting. The Bluejays were whistled for 25 fouls and Oklahoma scored 20 points at the line in 30 attempts.